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KMID : 1134820070360111377
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 11 p.1377 ~ p.1384
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Effects of Phyto?Extract Mixture (PEM381) in Type Ⅰ Allergic Reaction-Induced Mice
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Kim Kyung-Bum
Park Jeong-Su
Jeong Jong-Moon
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Abstract
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A previous study suggested that the phyto-extract mixture (PEM381) containing Camellia sinensis (leaf), Psidium guajava (leaf), and Rosa hybrida (flower) inhibited not only arachidonic acid cascade-related enzymes (5-lipoxygenase and cyclooxygenase) in vitro but also degranulation and histamine release from rat peritoneal mast cells. In this study, the same PEM381 was used to investigate its inhibitory effects on the syntheses of leukotrienes and prostaglandins as well as on serum concentration of histamine and eosinophils infiltration in type Ⅰ allergic reaction-induced mice. The PEM381 could decrease concentrations of serum cysteinyl leukotrienes from mice activated by anti-DNP IgE and DNP-albumin. The concentration of serum histamine by oral administration of PEM381 (25, 50, and 100 ㎎/㎏ of body weight) in type Ⅰ allergic reaction-induced mice was 395.93±190.37 nM, 315.59±164.23 nM, and 325.07±112.02 nM, respectively, while that of positive control (promethazine hydrochloride 10 ㎎/㎏ of body weight) was 270.12±24.02 nM. In addition, the PEM381 also showed inhibitory effect on the eosinophils infiltration in the nasal mucosa of mice which were sensitized with ovalbumin. However, the effect of PEM381 on the syntheses of prostaglandins seemed to be insignificant. Consequently, these results suggest that PEM381 may be useful for the prevention and treatment of type Ⅰ allergy-related diseases.
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KEYWORD
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PEM381, prostaglandins, leukotrienes, histamine, eosinophils
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